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First-in-human trial underway evaluating ATR-258's selective 2-adrenergic signaling in muscle Oral, first-in-class therapy aims to drive fat loss while preserving or increasing muscle mass Built on GRK2-biased signaling pathway to avoid traditional cardiovascular side effects Backed by 2025 Cell Press publication validating novel mechanism of action Signals growing momentum behind next-generation obesity therapies beyond GLP-1s ------------------------------------------------------------- Stay up to date with everything obesity through my newsletter To view or add a comment, sign in The ODYSSEY-#HCM findings were neutral from a clinical standpoint: Mavacamten use did not result in improved peak oxygen consumption or patient-reported health status in those with nonobstructive hypertrophic cardiomyopathy despite reverse remodeling as suggested by echocardiographic and plasma biomarker levels
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[14] Safety and Tolerability Profile GI events predominate but resolve with titration
Additionally, bedside microdialysis monitoring in patients with subarachnoid hemorrhage revealed that dynamic elevations of extracellular lactate and glycerol closely correlate with delayed cerebral ischemia, highlighting lactates utility as a sensitive indicator of acute metabolic distress in neurological injury [190]
