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Johns Hospital in Springfield, Ill

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Exenatide long-acting preparations were launched in the United States in 2012 and officially launched in 2018 with the approval of the National Medical Products Administration (NMPA)

Eur Arch Psychiatry Clin Neurosci 249(Suppl 3):6873 Eikelenboom P, Rozemuller AJ, Hoozemans JJ, Veerhuis R, van Gool WA (2000) Neuroinflammation and Alzheimer disease: clinical and therapeutic implications

Topical Administration (Most Common) The most widely used approach is topical application via DMSO (dimethyl sulfoxide): Dissolve 3-5mg Dihexa in a few drops of DMSO Apply to forearm skin (DMSO acts as a carrier to drive the peptide through the skin) DMSO concentration: ~20-30% in the solution Pros: Effective absorption, avoids injection Cons: DMSO has a strong garlic-like odor that can transfer to breath/skin Starting Dose Begin at 1-3mg topically to assess response Work up to 3-5mg if tolerating well Cycling Protocol Dihexa appears to have lasting effects that persist after stopping likely due to synaptogenesis (new connections don't disappear when you stop)