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While semaglutide targets the GLP-1 receptor alone, tirzepatide activates both GLP-1 and GIP receptors simultaneously, a dual mechanism that clinical trials suggest may drive greater weight reduction for certain individuals

Pregnancy or medical conditions sometimes require stopping semaglutide

Retatrutide skin effects A small proportion of study participants reported skin side effects with retatrutide (7%)

Counterfeit sleeping pills containing nitazines have caused a rash of overdoses in prisons in Ireland

Tiaminal B12 injection is also an option, with its own benefits

Edison P, Femminella GD, Ritchie CW, Holmes C, Walker Z, Ridha BH, Raza S, Livingston NR, Nowell J, Busza G, Frangou E, Love S, Williams G, Lawrence RM, McFarlane B, Archer H, Coulthard E, Underwood B, Koranteng P, Karim S, Bannister C et al (2021) Evaluation of liraglutide in the treatment of Alzheimers disease