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If you take an SSRI or SNRI for anxiety or depression, combining it with tramadol increases the risk of serotonin syndrome, a rare but serious condition

This doesnt mean that the medication is ineffective in the first 4-12 weeks

To examine the mental health effects of GLP-1s, researchers looked at outcomes during periods when participants were taking the medications and periods when they werent

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It is the well understood, controllable route, which is exactly why careful dosing and patient titration matter so much with it