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Further, the CVOTs in general also suggested a potential benefit of GLP-1 RAs on HF, positioning GLP-1 RAs as another advanced option alongside SGLT2 inhibitors in the otherwise sparse treatment armamentarium for especially HFpEF

The question is whether they're better, worse, or the same as comparator interventions producing similar magnitudes of weight loss

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Cochrane risk of bias (graph) for the 23 trials

[10] Comparative effectiveness: When compared to metformina commonly used insulin-sensitising medication for metabolic features of PCOSGLP-1 receptor agonists appear to produce greater weight loss