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Gallstone attacks and bile duct blockage: Rapid weight loss increases risk of gallbladder complications
It has a host of other benefits including nootropic effects and reducing triglycerides
So whats the problem
The Teichman 2006 trials showed IGF-1 increases of roughly 1.5 to 3-fold with DAC but did not measure fat mass or lean mass directly
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Currently, there is an ongoing randomised double-masked placebo-controlled trial, the SUMMIT trial, studying the efficacy and safety of tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and GLP-1 receptors, versus placebo in HFpEF patients with obesity (NCT04847557)
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