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Description

The receptor selectivity difference matters clinically because GIP activation independently promotes satiety, reduces appetite-driven eating, and may enhance energy expenditure through brown adipose tissue activation

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doi: 10.1016/j.nbd.2025.107124 221 MarsanE.VelmeshevD.RamseyA.PatelR

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& Graves, J

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For example, a large-scale study published in the Journal of the American Medical Association found that sertraline significantly improved symptoms of depression compared to a placebo

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