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H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)
Use of amitriptyline in the treatment of interstitial cystitis
Our data showed that MCD diet feeding induced obvious hepatic steatosis in mice as indicated by H&E and oil red O staining, and the increased hepatic TG levels
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