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Mitochondria are the main source of ROS in response to oxidants 7 , and play dominant roles in apoptosis 53,54,55,56,57,58 and necrosis in RPE cells 59,60

The peptide binds copper with extraordinarily high affinity (pK = 16.44), which is roughly 10 million times higher than other tripeptides and comparable to albumins copper binding

Several factors converge to make the assessment of neuroprotection in humans particularly challenging, including the inability to obtain brain biopsies, the lack of reliable biomarkers, species-specific differences in microglial responses, and suboptimal patient stratification

Carvas, A

Rojo, A

Such models will further contribute to the investigation of genetic and environmental factors in the autoimmune development of thyroid disorders and, as such, will be an important tool for therapeutic development (Capuzzo 2021)