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El inicio debe ser con dosis bajas y se va aumentando en forma progresiva en funcin de la tolerancia, para evitar los efectos adversos
In the orforglipron groups, 9% and 10% of patients stopped treatment in the 12 mg and 36 mg doses respectively
197 Tumor cells adapt by upregulating BER components (e.g., Pol, APE1, FEN1) and scaffolding proteins such as CUX1/2 and SATB1 to promote repair and evade senescence
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Interestingly, one study suggested that if there is increased inflammatory bowel disease, it is associated with the acne and not with the therapy
