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Tirzepatide is expected to show similar or better results, but until SURPASS-CVOT is completed, semaglutide maintains an advantage in this domain
Patients with statin intolerance should first consider evidence-based alternatives like ezetimibe, bempedoic acid, PCSK9 inhibitors, or inclisiran before considering GLP-1 therapy primarily for lipid management
The STEP trials found that people who stayed on semaglutide for two years maintained their weight loss and continued to show improvements in HbA1c, fasting glucose, triglycerides, and inflammatory markers
Chakrabarty K, Bhattacharyya S, Christopher R, Khanna S
Review eligibility criteria (generally BMI 27-30, age 18+, specific comorbidities)
Possible Side Effects of Excessive Vitamin C While Vitamin C is beneficial, excessive use can lead to skin irritation, redness, or sensitivity, particularly for those with sensitive skin
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