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As people age, the production of hyaluronic acid decreases, leading to drier and less elastic skin

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The loss of collagen leads to fine lines, wrinkles, and saggy skin, making people look older than they are

Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids

It undergoes enzymatic conversion to pantothenic acid which is a key component of coenzyme A involved in protein and lipid metabolism