Evaluation of aerosol delivery of nanosuspension for pre-clinical pulmonary drug delivery
GSH biosynthesis occurs exclusively in the cytosol via a two-step ATP-dependent reaction catalysed sequentially by two enzymes: gamma-glutamylcysteine synthetase (GCL also referred to as gamma-glutamylcysteine ligase, comprising the catalytic GCLC subunit and regulatory GCLM subunit), which catalyses the rate-limiting first step of joining glutamate and cysteine
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A key factor in this vulnerability is the age-related decline in immune function, a phenomenon known as immunosenescence, which affects both innate and adaptive parts of the immune system
Theoretical concerns include growth factor-related effects in individuals with existing malignancies and immune modulation in vulnerable populations
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