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If these ROS overwhelm the cellular antioxidant response, cell death and tissue necrosis occurs, resulting in severe hepatotoxicity that can lead to death 6

Central to this mechanism is the upregulation of Chac2, an enzyme that promotes GSH accumulation

[4] Without continued treatment, most patients regain 6080% of lost weight within 12 years

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Avoid high-fat meals during the first 4 weeks of retatrutide