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The mechanisms and regulation of autophagy and mitophagy have attracted considerable attention due to their impact in health and disease and have been recently reviewed ( Atg5 , an essential gene that regulates autophagy, has been shown to protect against APAP-induced liver injury due to compensatory mechanisms ( Atg5 suppresses autophagy and p62 degradation, which results in the persistent activation of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) by releasing the inhibition of KEAP1 on NFE2L2
Topiramate can decrease sweating and increase body temperature, leading to life-threatening dehydration
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Busse E, Zimmer G, Schopohl B, Kornhuber B
Blackford, A
The Ozempic lawsuit, filed against pharmaceutical giants Novo Nordisk and Eli Lilly, alleged that the drugs, both Glucagon-like peptide 1 (GLP-1) agonists, caused severe gastrointestinal issues.
