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Recent studies of isolated L-cells (95) and a L-cell derived cell line, GLUTag cells, have shown stimulation of GLP-1 secretion by glucose acting to inhibit K+ channels as in islet beta cells, by activation of the SGLT-1 transporter leading to depolarization (91), or activation of sweet taste receptors (T1R2 / T1R3) which activate Gq and PLC
10.1016/j.yexcr.2009.04.009 48 McDonnellD
B.LambertL.KinnearE.BusseD.ErbarS.ReuterK
The contrast with semaglutide's simpler escalation is documented in the semaglutide dosing guide
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