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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)

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Among the 50 generated conformations, the optimal docking result was selected based on Gibbs free energy, and further downstream analysis was focused on this highly ranked conformation

13 High costs, technical complexity, and limited throughput restrict their accessibility