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High-dose oral B12 supplements are available over the counter for a few dollars per month, while injection visits typically involve copays, administration fees, and the time cost of repeated clinic appointments

Because GHK-Cu is naturally present in the body, serious adverse effects are uncommon when used under medical supervision at appropriate doses

use is typically under a licensed clinicians supervision for research or compounded medical use

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William Castle demonstrated that gastric juice contained an "intrinsic factor" which when combined with meat ingestion resulted in absorption of the vitamin in this condition