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Losing a significant amount of weight alters how the body distributes pressure across the spine

Discontinuation because of gastrointestinal adverse reactions occurred in 3.1% and 3.8% of treated patients versus 0.4% on placebo

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Patients with DPN would likely experience symmetric pain or discomfort, typically presenting as numbness, burn-like or sting-like pain, and the feeling of wearing stockings or gloves (4)

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