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The risk of systemic copper overload is negligible when used topically at recommended concentrations

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The study also confirmed that exercise induces endogenous MOTS-c production in human skeletal muscle, establishing a bidirectional relationship between MOTS-c and physical activity (Reynolds JC et al., Nat Commun

Its selectivity for central melanocortin receptors underlies its prosexual effects without altering hormone levels 1-4

If you're low in them, topping them up helps that machinery work properly