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These medications work through different mechanisms than metformin, making them complementary rather than conflicting treatments

For example, combining anti-Flt1 antibodies loaded with gemcitabine with PEG-polyamidoamine (PAMAM) dendrimer macromolecule complexes in tumor-bearing mouse models can significantly reduce the number of myeloid cells and enhance the efficacy of gemcitabine in treating tumors (129)

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Receptor recovery is actively occurring during this window