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The Itga8-Cre/Itga8-CreERT2 model avoids myeloid cell leakage and does not induce the lethal visceral myopathy commonly seen in Myh11-driven models, making it an ideal tool for studying VSMC sex differences and remodeling processes [238, 239]
However, if a large number of Heinz bodies are produced, as occurs in G6PD deficiency, some Heinz bodies will be visible when viewing RBCs stained with crystal violet
5 and Supplementary Data 5)
While the latter might be relevant to conditions such as pathogen challenge, current concepts suggest that the relatively low antioxidant complement of the apoplast enables this compartment to exist in a more oxidized state compared to the cell interior (Pignocchi et al
Available at: fda.gov/fdac/features/1998/498_pd.html
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