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Participants saw the largest weight reduction when prescribed the maximum dose of tirzepatide (between 10 and 15 milligrams)
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This difference allows compounding under Section 503A to potentially continue, provided the prescribing physician documents a specific clinical reason for the compounded version over the commercial product
In SURPASS-2, for example, participants receiving 15 mg of tirzepatide experienced average HbA1c reductions of 2.3% and weight loss of 12.4 kg, significantly outperforming semaglutide [9]
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