Additional insights into this topic comes from Marzieh Salehi and colleagues in a paper just published in Diabetes
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Dose adjustments of these agents are likely to be necessary under medical supervision
On paper, that might sound like a clever workaround
In the SURMOUNT-5 trial, which directly compared the two medications, Mounjaro 15 mg produced 20.2% weight loss, while Wegovy 2.4 mg produced 13.7% over 72 weeks
Specifically, treatment with exenatide acetate increased the ratio of p -AMPKThr172/AMPK, inhibited NF-B p65 phosphorylation, and downregulated pro-inflammatory markers, including IL-1 and TNF- [69]