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An initial electron leak from complex III of the electron transport chain results in the release of free radicals into the intermembrane space and cytosol without influencing mitochondrial function [29]
At therapeutic doses, the small amount of NAPQI produced is neutralized by conjugation with reduced glutathione (GSH), as shown in Figure 1, a crucial tripeptide that, in an NADPH-dependent reaction, helps detoxify oxidants like NAPQI
Adjunctive sertraline for asymptomatic cryptococcal antigenemia: a randomized clinical trial
77Colombel J-F, Sandborn WJ, Ghosh S, et al
Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs
413 Furthermore, the downregulation of ZIP7 promoted the cleavage of PARP, enhanced the expression of Bad, Caspase-9, and cleaved-Caspase-3, and suppressed Bcl-2 expression in CRC
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