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Giaconi is health sciences professor of ophthalmology at the Stein Eye Institute and David Geffen School of Medicine at UCLA

Retatrutide demonstrated favorable effects on cardiometabolic markers, including reductions in non-HDL cholesterol, triglycerides, and high-sensitivity C-reactive protein (hsCRP)

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What this basically means is that the ordinary neurochemicals needed within the sympathetic nervous system can go on to stimulate hyper-excitable sensory cells in the DRG, and this produces the sensation of pain