| Category | Zepbound | Mounjaro | |-----------------------------------|------------------------------------------------|------------------------------------------------| | FDA Approval Indication | Obesity and overweight management (with comorbidities) | Type 2 diabetes management | | Year of FDA Approval | 2023 | 2022 | | Active Ingredient | Tirzepatide | Tirzepatide | | Dose Range | 2.5 mg to 15 mg once weekly | 2.5 mg to 15 mg once weekly | | Primary Clinical Purpose | Weight loss | Blood sugar control | | GLP-1/GIP Activity | Dual agonist (GLP-1 + GIP) | Dual agonist (GLP-1 + GIP) | | Average Weight Loss (in trials) | Up to 22.5% of body weight in SURMOUNT-1 study | Up to 15% of body weight in SURPASS studies | | Insulin Sensitivity Impact | Improves insulin sensitivity in patients with obesity | Improves insulin sensitivity in type 2 diabetes patients | | Delivery Method | Single-use auto-injector pen, subcutaneous injection | Single-use auto-injector pen, subcutaneous injection | | Dosing Frequency | Once weekly | Once weekly | | Manufacturer | Eli Lilly | Eli Lilly | | Common Side Effects | Nausea, vomiting, diarrhea, constipation, decreased appetite | Nausea, vomiting, diarrhea, constipation, decreased appetite | | Insurance Coverage | Variable

The difference now is that one to two beers feel like enough
By reducing hunger and making it easier to feel full, semaglutide helps people eat less without feeling deprived
The Lists annual revision process is led by WADA, beginning with an initial meeting in January and concluding with the publication of the List by 1 October
I think these medications are changing lives and saving lives, Hostin said
The app's focus on protein-first eating aligns with clinical recommendations for patients experiencing medication-induced appetite suppression