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Taken together, HPA axis dysregulation represents a shared neuroendocrine pathway linking chronic stress, metabolic dysfunction, and mood disorder progression
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thus, Ex-4 treatment improves BBB integrity and reduces the microglial priming associated with aging [68]
Unlike peripherally-acting sexual dysfunction medications that enhance blood flow, PT-141 modulates brain circuits involved in sexual desire and arousal, representing a fundamentally different therapeutic approach
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Nature Reviews Drug Discovery
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