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Alzheimers Dis.: JAD 98 , 925940 (2024)

Vitamin D and vitamin B12 are particularly important to monitor during Zepbound therapy, as many adults have suboptimal levels even before starting treatment

The principles apply equally to tirzepatide users

Clinical trials show approximately 2040% of total weight lost with GLP-1 medications includes lean mass, comparable to dietary restriction and bariatric surgery

When stratified by menopausal proxy, premenopausal-proxy women younger than 50 years (n = 57,132) experienced a 29% lower hazard of death with GLP-1 RA use (hazard ratio, 0.71

Each person was given 3 mg of vitamin B12 in one form, waited 14 days for a wash out period, and then took the other form (N=18)