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These include promoting the growth of beneficial bifidobacteria, balancing the ratio of Firmicutes to Bacteroidetes, stimulating mucin secretion, up-regulating proteins involved in maintaining tight junctions, preserving the integrity of the gastrointestinal mucosal barrier, preventing bacterial adhesion to the gut epithelium, reducing circulating levels of bacterial lipopolysaccharides, and down-regulating the expression of the TLR4 gene [27, 82,83,84]

M., Gibb, R

Here's what the current long-term data shows, drawn from TRIUMPH-4 and TRIUMPH-1: Source: TRIUMPH-4 (N=445, 12mg dose, 68 weeks) and TRIUMPH-1 (N=2,339, 80 weeks + 104-week extension)

GIP adds metabolic improvements through pancreatic and fat tissue effects

Haemostasis 20 , 147154 (1990)