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More extensive, long-term clinical trials are urgently needed to fully elucidate its efficacy, safety profile, and optimal dosing strategies compared to established injectable formulations
In addition, semaglutide was associated with a significant 26% reduction in major adverse cardiovascular events compared to placebo in a preapproval cardiovascular outcomes trial (CVOT)
Given the poor bioavailability of oral NAD+ and its precursor vitamins through supplements (and why most wellness supplements have limited benefit), IV or subcutaneous routes are necessary to achieve the serum concentrations observed in the published research
To put them into a practical protocol: Week 1 elimination phase
Endocr Pract (2021) 27(6):62635
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