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Bioactive oligopeptides in dermatology: Part I

Studies confirm 50% drops by midlife, linking to aging symptoms.[1][9] Restoring NAD+ has been shown in animal studies to improve lifespan and healthspan, with human trials indicating benefits in muscle function and cognitive performance

10.1371/journal.ppat.1000213 PLOS Pathog

However, these associations likely reflect underlying disease processes rather than B12 toxicity itselfelevated B12 is often a marker of serious illness rather than its cause

For the chronic dosing studies, most studies are looking at doses of 4 g/day.[ref] (This used to be the maximum recommended acetaminophen dose per day, but that has now changed to 3g/day.) For reference, a single over-the-counter Extra Strength Tylenol is 500 mg, with the directions saying not to exceed 6 tablets in 24 hours (so 3g/day)