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Abrupt discontinuation without a management plan may result in weight regain and deterioration of glycemic control in individuals with diabetes

Aardvark Therapeutics Sector: Oral gut-restricted bitter taste receptor agonists for hunger suppression HQ: San Diego, CA Year Founded: 2017 Origin Story: Aardvark Therapeutics was founded around a mechanistically distinct hypothesis: rather than suppressing appetite like GLP-1 drugs, the companys lead compound activates bitter taste receptors (TAS2Rs) confined to the gastrointestinal tract to trigger local release of satiety hormones, targeting hunger itself without systemic drug exposure

GHK-Cu and AHK-Cu are at very different stages of their research journeys, which matters when you're deciding how much confidence to put in marketing claims

CYP3A4 inducers are ubiquitous and rev up the enzyme to varying degrees