To summarise, ageing is accompanied by significant decline in astrocytic haemostatic and neuroprotective capacities, which may directly affect nervous tissue and increase it vulnerability to pathological attacks and neurodegeneration
Many emerging intervention strategies are already under investigation
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Interestingly, we also found that splicing of E35a is neuronal activity-dependent through our reanalysis of published RNA-seq datasets 43,44
Staus, D
Here, we provide an overview of some of the best-described mechanisms, such as hypusination, autophagy, and pathways linked to oxidative stress
