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Therefore, FXR signaling can modulate the gut microbial composition and regulate hepatic metabolism
The new indication could give Novo Nordisk a boost against rivals in the GLP-1 agonist class, including Eli Lilly, whose dual GIP/GLP-1 agonist Mounjaro (tirzepatide) competes in the diabetes category and is in a phase 3 trial (TREASURE-CKD) looking at a CKD indication in people with obesity, with and without diabetes
10.1056/NEJMoa2206038 43 JonesB.BuenaventuraT.KandaN.ChabosseauP.OwenB
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Researchers should adhere to applicable guidelines for research chemical handling and ensure appropriate oversight for any long-term study protocol involving these compounds
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