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Similarly, medical studies report that new GLP-1 prescriptions have become predominantly for obesity rather than diabetes: e.g., in 20192023 only ~57% of new GLP-1 patients had T2D (down from ~65% a decade earlier) ( [27] ) ( [28] )

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Therefore, employing a multimodal approach and combining SGLT2 inhibitors with agents that work via different mechanisms (e.g., GLP-1 agonists and metformin), in addition to dietary and lifestyle modification, are imperative to ensuring that the patients weight loss is maintained

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AOD-9604 is not FDA-approved for any indication, and all use represents off-label application requiring informed medical decision-making