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The Tagliolatto group and others have demonstrated measurable dermal collagen reorganisation on histology at six months post-treatment

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Modulating NAD metabolism, histone modifiers (e.g., EZH2), or ATP-dependent chromatin remodelers (e.g., BRG1, CHD4) may shift the balance of repair pathway utilization, destabilize replication forks, or impair lesion recognition