The STEP 5 data suggests that ongoing administration is necessary to maintain results, as participants who discontinued semaglutide in the STEP 1 extension study regained approximately two-thirds of the weight they had lost within one year of stopping
These trials provided the years of data necessary for the FDA to determine that the benefits of the medication outweighed the potential risks for chronic weight management
For constipation, osmotic laxatives like polyethylene glycol are generally preferred
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Nonaka H, Ohue-Kitano R, Masujima Y, Igarashi M, Kimura I
The modifications in the latter work primarily to increase the half-life of the peptide from 5-10 mins for sermorelin, to around 30 mins [13, 14]