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By contrast, cancer cells typically co-express MCT1 and MCT4, facilitating highly efficient lactate efflux that preserves intracellular pH homeostasis even within the acidic tumor microenvironment (127)

This underscores the key issue: a trial powered to identify and confirm efficacy in specific, responsive genetic subsets would be highly complex and require substantial patient numbers to stratify by mutation type

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Polyurea dendrimer for efficient cytosolic siRNA delivery

Thioredoxin targets of developing wheat seeds identified by complementary proteomic approaches