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This multi-system action explains why weight loss occurs even in patients without insulin resistance or prediabetes
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New England Journal of Medicine , 2025
Zhong, L., Liu, J., Liu, S
A fixed dose-escalation procedure was used, with a starting dose of 0.25 mg for 4 weeks that escalated to 0.5 mg for 4 weeks until the maintenance dose (0.5 mg or 1.0 mg) was reached
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