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To maintain optimal B12 levels, regular injections may be necessary, typically every few weeks or months
The answer depends on your treatment duration, dose level, and individual metabolic response, but evidence suggests a structured approach minimizes rebound weight gain
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doi:10.1016/j.ijdevneu.2007.08.004 Stefanello FM, Matte C, Pederzolli CD, Kolling J, Mescka CP, Lamers ML, de Assis AM, Perry ML, dos Santos MF, Dutra CS, Wyse ATS (2009) Hypermethioninemia provokes oxidative damage and histological changes in liver of rats