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Older adults and those with compromised antioxidant systems may require lower starting doses with gradual titration based on tolerance and biomarker response

TGR5-mediated stimulation of GLP-1 secretion was dependent on cAMP formation and was blocked by inhibitors of adenylyl cyclase (Katsuma et al., 2012)

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Acute pancreatitis is rare but requires immediate medical attention

This lends support to the researchers idea that LBM is not equal to muscle mass and that other tissues can contribute to LBM loss considerably