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Another study reported that TLR4 mutant mice fed HFD showed neurovascular protection by improving astrocytic vascular recovery and cerebromicroenvironement [143]

Next, the cleavage of GSDMD (gasdermin D) by caspase 1 and caspase 11 to produce the N-terminal fragment of GSDMD (N-GSDMD) is a critical event in the lethal cascade driving infection-associated pyroptotic cell death [118, 119]

PMID: 29909968