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However, repeated exposure to the mitochondrial superoxide generator rotenone during NSC differentiation results in the decreased production of neuronal cell types, including dopaminergic neurons (Pistollato et al., 2017), inferring that NRF2 activation may not be able to fully compensate for excessive exogenous insult

For a 5mg vial reconstituted with 2mL bacteriostatic water: 5mg 2mL = 2.5mg/mL (or 2500mcg/mL)

Journal of natural toxins 11(4):329335

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The degradation of free heme as a proinflammatory mediator indicates the anti-inflammatory effects of HO-1