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Its active compounds enhance GLP-1 secretion from intestinal L-cells while increasing GLP-1 receptor sensitivity, helping improve glucose metabolism, reduce lipid accumulation, and support weight management through activation of important metabolic pathways like AMPK-signaling
Severe, persistent vomiting that prevents you from keeping down fluids for more than 24 hours risks dehydration and electrolyte imbalance
However, its important to note that real-world outcomes often fall short of clinical trial results due to adherence challenges
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Retatrutide also improved multiple cardiometabolic parameters, including blood pressure, lipids, waist circumference, and liver fat (82% reduction in hepatic steatosis)
In the meta-analysis, the different follow-up periods across studies were included, which could increase the chance of heterogeneity
