Research suggests, however, that health professionals may need to be more attentive to an often-ignored drug side effect: severe depression
Around 3,800 participants were enrolled across both trials, randomized to placebo or oral semaglutide 14 mg daily for up to 104 weeks (~2 years)
Lastly, the limited evidence on the effects of GLP-1 RAs on key pathognomonic proteins, A and -synuclein, weakens the scientific basis for considering GLP-1 RAs as major game-changers for neurodegenerative diseases
The official prescribing information lists nausea, vomiting, diarrhea, abdominal pain and constipation among the most common adverse reactions reported with Ozempic
Understanding the broader GLP-1 and fatigue connection helps contextualize why tiredness during treatment can feel so pervasive
Neuen BL, Oshima M, Agarwal R, Arnott C, Cherney DZ, Edwards R, et al