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Methods A total of 100 overweight or obese women with PCOS diagnosed according to the Rotterdam criteria were randomly assigned to two groups: MET (1000 mg twice daily [BID] for 16 weeks) and combination therapy (COM) (1000 mg MET BID plus 1- mg semaglutide once weekly [QW] for 16 weeks)
Who Can Benefit From the Procedure
Adverse events were reported in 73% to 94% of the treatment groups and in 70% of the placebo group
The titration schedule is a maximum framework, not a mandatory escalation
For the IV regimen, a loading dose of 150 mg/kg in 200 cc is given for 15 minutes, followed by 50 mg/kg in 500 cc over 4 hours and then 100 mg/kg in 1000 cc over 16 hours
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