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ERS activating unfolded protein reaction (UPR) pathways is recognized by 3 sensors in endoplasmic reticulum (ER) membrane: protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring protein 1 (IRE1), and cyclic AMP-dependent transcription factor 6 (ATF6)
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Furthermore, a subpopulation of promyelocytic leukemia zinc finger + -T cells were found to be involved in the age-related accumulation of adipose Treg cells by producing IL-17A [93]
Staying within recommended dosages can help minimize these effects
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