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LigBuilder 2: a practical de novo drug design approach

New blood vessels in injured tendon tissue mean better delivery of oxygen, nutrients, and resident repair cells, which is plausibly why the peptide shows up first in tendon-healing models

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Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation

Bulk RNA sequencing revealed that gene expression changes were most pronounced in the MBH, where RAMP1/3 KO mice treated with sCT showed extensive differential expression of over 1,700 genes, while WT mice exhibited comparatively minor transcriptional shifts