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Stroke 45:34033411 He Y, Hara H, Nez G (2016) Mechanism and regulation of NLRP3 inflammasome activation

A practical design principle is dual or sequential subcellular targeting, in which a mitochondria-enriched motif is combined with a second motif that biases accumulation at a partner compartment such as the ER, increasing the probability that payloads reside near contact zones where calcium, redox and lipid exchange are integrated

PMID: 22950504

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Can Taking Glutathione Damage Your Kidneys

Tesamorelin's longer half-life and ipamorelin's roughly two-hour window are reflected in how those compounds were scheduled in research, whereas sermorelin's very short half-life shaped its own study designs